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RDefining your research

Get access to RDefine's preclinical and translational services to help your research.

ANIMAL MODELS
of human diseases

Committed to promoting animal-friendly policies, we are developing eco-friendly technologies that play a pivotal role in accelerating the development cycle for advanced pharmaceuticals and health products based on fully characterized genetic, toxin, surgical, or diet-induced rodent models that closely resemble human health issues.

Our team has in-house expertise within a whole range of diseased-animal models:

Metabolic

Cardiovascular

Gastrointestinal

Renal

Autoimune disorders

Neurodegenerative

Neuropsychiatric

Others

Genetically - Induced

  • Apo-E KO mice
  • 3xTG-AD mice
  • SIRT-KO
  • db/db and ob/ob mice
  • Zucker Diabetic Fatty rats
  • Non-obese diabetic (NOD) mice
  • Spontaneously Hypertensive Rats (SHR)
  • Dahl salt-sensitive rats 
  • Others

Diet - Induced

  • Renal disease (Adenine-enriched diet)
  • Metabolic disease (High-fat/High-carbohydrates diets)
  • Hematopoietic disease (Iron-deficient anemia);
  • Peripheral neuropathy (High-fat diet)
  • Non-alcoholic steatohepatitis (Western diet)
  • Others

Toxin - Induced

  • Multiple Sclerosis (Cuprizone and EAE intoxication)
  • Parkinson’s disease (MPTP, Rotenone and 6-OHDA intoxications)
  • IBD (TNBS and DSS intoxication)
  • Bladder cancer (N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) intoxication)
  • Pulmonary hypertension (Monocrotaline induced)
  • Type 1 Diabetes (STZ and alloxan intoxication)
  • Kidney injury (Folic acid and cisplatin intoxication)
  • Liver injury (Carbon tetrachloride (CCl4) intoxication)
  • Hypertensive Heart Disease (angiotensin II or aldosterone intoxication)
  • Pulmonary Heart Disease (monocrotaline intoxication)
  • Autism Spectrum Disorders (In utero Exposure to Valproic-Acid)
  • Others

Surgically - Induced

  • Renal disease (5/6 Nephrectomy, Unilateral Ureteral Obstruction and bilateral clamping of renal arteries and veins)
  • Neuropathic pain (partial sciatic nerve ligation)
  • Heart Failure (transverse aortic constriction)
  • Others

Preclinical In-Vivo and Ex-Vivo Services

Customized services tailored to meet the specialized needs of your research project.

We offer a whole range of services that will help you find solutions that better explain a drug’s mechanism of action, and find potential biomarkers by combining our services.

As partners, you can rely on our scientific experience at every step of your preclinical and translational drug development project.

Our approach ensures a smooth transition from preclinical to clinical studies, so you can get the most out of your studies and help with your preclinical drug development efforts.

We have a whole range of highly qualified services that will help you find tailored solutions to meet your needs and better disclose drug’s mechanisms of action.

LEARN ABOUT TAILORED SOLUTIONS

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in VIVO

– Acute and repeated-dose toxicity studies

– Optimal dose determination studies

– Therapeutic efficacy studies

– Animal model set up and validation

– Phenotyping screening and behavioral analysis 

– Functional studies

ex VIVO

– Tissue & organs collection, preservation & processing

– In vivo target identification & validation

– Microscopic analysis (histopathologic assessment,
immunofluorescence, immunohistochemistry)

– Immunophenotyping

– Gene and Protein Expression

Scientific Consulting

RDefine offers you specialized preclinical R&D services, focused on animal-friendly testing, to empower your research process.
We support every step of your drug RD process, so you don’t have to worry about protocols, study monitoring and much more.
Our team can provide you with: 

  • STUDY MONITORING

Rely on our specialized skills to efficiently support and manage your animal studies

  • PRECLINICAL REGULATORY SUPPORT

We assist you in the early regulatory engagement with legal authorities, including animal use licensing and approval

  • EXPERIMENTAL DESIGN

Our team provides you specialized guidance in experimental design and crafting to ensure reproducibility and impactful results

  • PROTOCOL DEVELOPMENT

We implement and develop in vivo protocols, leveraging animal-friendly practices, optimizing the research process towards efficiency and precision

  • STATISTICAL CONSULTANCY

Get access to our advanced statistical analysis and graphical representation of scientific data. We provide valuable insights to enhance the interpretation and presentation of your findings from animal studies

  • SCIENTIFIC & MEDICAL WRITING

RDefine compliant Preclinical Evaluation Reports with our professional writing services for effective and impactful communication of scientific papers, posters and presentations.

LET US ASSIST
your research

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